- SpringerBriefs in Statistics | Springer
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- Free Experimental Epilepsy [Prog. In Brain Research Vol 19] 1965
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In clinical trials this is the smallest difference that you believe would be clinically important and biologically plausible. In a study of association it is the smallest change in the dependent outcome variable, response , per unit change in the independent input variable, covariate that is plausible.
SpringerBriefs in Statistics | Springer
Parallel design: A parallel designed clinical trial compares the results of a treatment on two separate groups of patients. The sample size calculated for a parallel design can be used for any study where two groups are being compared. Crossover study: A crossover study compares the results of a two treatment on the same group of patients. The sample size calculated for a crossover study can also be used for a study that compares the value of a variable after treatment with it's value before treatment. The standard deviation of the outcome variable is expressed as either the within patient standard deviation or the standard deviation of the difference.
Clinical Data Analysis on a Pocket Calculator
The former is the standard deviation of repeated observations in the same individual and the latter is the standard deviation of the difference between two measurements in the same individual. Study to find an association: A study to find an association determines if a variable, the dependent variable, is affected by another, the independent variable. For instance, a study to determine whether blood pressure is affected by salt intake.
Measurement: The outcome of the study is a continuous measurement. Time to an Event: The outcome of the study is a time, such as the time to death, or relapse.
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Free Experimental Epilepsy [Prog. In Brain Research Vol 19] 1965
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